Tissue Regeneration & Therapeutics

In the field of biology, regeneration is the progression of renewal, regeneration, and growth that makes it possible for genomes, cells, organ regeneration to natural changes or events that cause damage or disturbance. This study is carried out as craniofacial tissue engineering, in-situ tissue regeneration, adipose-derived stem cells for regenerative medicine which is also a breakthrough in cell culture technology.

Stem cell-based therapy has been studied to achieve an alternative to current solutions offered by modern medicine. The uses of adult stem cells focused on for regeneration. This unique population of multipotential cells has been isolated from various sources, including bone marrow, adipose, and muscle tissues. Genetic engineering of adult stem cells has led to repair and rapid formation in vivo. It is hypothesized that these genetically modified cells exert both autocrine and paracrine effects on host stem cells, leading to an effect. The use of direct gene delivery has also shown much promise for in vivo repair. Several viral and non-viral methods have been used to achieve substantial bone tissue formation in various sites in animal models. To advance these platforms to the clinical setting, it will be mandatory to overcome specific hurdles, such as control over transgene expression, viral vector toxicity, and prolonged culture periods of therapeutic stem cells. This review covers a prospect of cell and gene therapy for repair.