Stem Cell apoptosis and signal transduction

Apoptosis, a molecularly regulated form of cell death, is essential for the normal functioning and homeostasis of most multicellular organisms. Apoptosis is regulated by some of the same signal transduction pathways previously implicated in other physiological cellular responses. Self-renewal and proliferation of stem cell population are controlled by Apoptosis. Apoptosis of stem cells is believed to be a dynamic process which changes in response to environmental conditions. Controlling apoptosis is also an important focus for studies of stem cell transplantation. Exploiting the full therapeutic potential of stem cells will require full interpretation of the signal transduction avalanches for proliferation, differentiation, and apoptosis.