Reprogramming Stem Cells: Computational Biology

Computational biology, a branch of biology involving the application of computers and computer science to the understanding and modeling of the structures and processes of life. It entails the use of computational methods for the representation and simulation of biological systems, as well as for the interpretation of experimental data, often on a very large scale. The fields of stem cell biology and regenerative medicine research are fundamentally about understanding dynamic cellular processes such as development, reprogramming, repair, differentiation and the loss, acquisition or maintenance of pluripotency. In order to precisely decipher these processes at a molecular level, it is critical to identify and study key regulatory genes and transcriptional circuits. Modern high-throughput molecular profiling technologies provide a powerful approach to addressing these questions as they allow the profiling of tens of thousands of gene products in a single experiment. Whereas bioinformatics is used to interpret the information produced by such technologies.