Cancer Stem Cells

The cancer stem cell (CSC) concept was proposed four decades prior and expresses that tumor development. Cancer stem cells are rare immortal cells within tumors that can both self-renew by dividing and give rise to many cell types that constitute the tumors, and can, therefore, form tumors. CSCs are forming tumor (tumorigenic) that contrast to other non-tumorigenic cancer cells. Those cells are hypothesized to persist in tumors as a distinct population and cause relapse and metastasis by giving rise to new tumors. Therefore, development of specific therapies targeted at CSCs holds hope for improvement of survival and quality of life of cancer patients, especially for patients with metastatic disease. Such cells have been found in various types of human tumors and might be attractive targets for cancer treatment rise to new tumors.